We are thrilled with the Rigaku X-ray generator and Saturn CCD
detector combination in our X-ray Core Facility at the University of
Puerto Rico.
Recently, we were able to collect 1.09 Å data on our
Rigaku system that allowed us to see the conformational changes that
take place in blackfin tuna myoglobin upon S-nitrosylation (Journal of
Biological Chemistry, 282 (2007) 19773).
This post-translational
protein modification is extremely sensitive to X-ray radiation, so we
were not able to collect synchrotron data and had to use our home
source. The sensitivity of the Saturn CCD detector allowed us to
minimize the exposure times and still collect atomic resolution data
that was necessary to deconvolute multiple conformations of the
S-nitrosylated cysteine.
—Dr. Eric R. Schreiter
Director, X-ray Crystallography Core Facility
Protein Research and Development Center
University of Puerto Rico
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