Structure-based drug design
Structure-based drug design (SBDD, also known as rational drug design) is a technique that accelerates the drug discovery process by utilizing structural information to improve the lead optimization process. It has been estimated that SBDD can reduce the cost from target identification to investigational new drug (IND) filing by 50%. The technique requires a high-resolution 3D structure of the inhibitor bound to the target obtained using X-ray crystallography. Once the structure is obtained, the interactions between the inhibitor and the active site of the target are analyzed. Improved inhibitors result from this analysis, resulting in a shortening of the lead optimization process.
Solutions
- Macromolecular crystallography systems: Ultimate HomeLab™